Sat May 22

7:00 - 8:00 Breakfast

8:00 - 10:00 Session 1: Introductory Comments and Concepts

• Charles Eaton MD:  Introductory Remarks.  Video
• Wolfgang Wach PhD:  The Development of the Dupuytren Society.  Video
• Lee Osterman MD:  Cline’s contracture: Dupuytren was a thief. A history of surgery for Dupuytren’s contracture. Video
• Ghazi Rayan MD:  Dupuytren's disease: anatomy, pathology, presentation. Video
• Ardeshir Bayat MD PhD:  Genetics of Dupuytren's.
• Albrecht Meinel MD:  The palmar fibromatosis or the loss of flexibility of the palmar finger tissue. A new insight into the disease process of Dupuytren’s contracture based on clinical and anatomical findings.
• Hanno Millesi MD: Changes of the visco-elastic properties of the palmar fascia as pathogenetic basis of Dupuytren’s Disease.
• Sandip Hindocha MD: Frequency of primary and incidence of recurrent Dupuytren's disease significantly impacts on the cost to the health service.
  

10:00 - 10:15 Break

10:15 - 12:15 Session 2: The Myofibroblast

• Paul Werker MD PhD: Management of soft tissue contractures: a surgical perspective Video
• Paul Zidel MD MS: Dupuytren’s versus burn scar contracture.
• Boris Hinz PhD: Fundamental aspects of myofibroblast contraction.
• Sem Phan PhD MD : Mechanisms of myofibroblast differentiation.
• Véronique Moulin PhD : Tissue engineering and the myofibroblasts.
• Giulio Gabbiani PhD MD: The N-terminal peptide of a-smooth muscle actin Ac-EEED inhibits myofibroblast contraction: therapeutic implications.
• Heinrich Seegenschmiedt MD: Review Of Radiotherapy For Morbus Dupuytren & Ledderhose.

12:15 - 1:00 Lunch

1:00 - 3:00 Session 3: Demographics and Genetics

• Sandip Hindocha MD: Familial pattern and inheritance of Dupuytren’s Disease: a comparison of populations and pedigrees in the UK and Iceland.
• Guido Dolmans MD: A clinical genetic study of familial Dupuytren’s Disease in the Netherlands.
• Vilhjalmur Finsen PhD: The epidemiology of Dupuytren’s disease in Bosnia.
• Hans Hennies PhD: Characterization of the epidemiology and genetic basis for Dupuytren Contracture.
• Guido Dolmans MD: A first genome-wide association study in Dupuytren’s disease.
• Sandeep Kathju MD PhD: Establishing an animal model of Dupuytren’s contracture by  profiling genes associated with fibrosis.
• Sandra Kraljevic Pavelic PhD: Microarray expression analysis of Dupuytren´s contracture.
• Guido Dolmans MD: Linkage analysis in six Dutch families with Dupuytren’s disease.
  

3:00 - 3:15 Break

3:15 - 5:15 Session 4: Collagen and Cell Biology

• Susan Hart VMD PhD: A primer of collagen biology:  synthesis, degradation, subtypes and role in Dupuytren’s contracture.
• Janine Morris PhD: Collagen degradation and the expression of proteases involved in collagen metabolism in the contraction of collagen gels by Dupuytren’s disease-derived fibroblasts.
• Martin Robson MD: Using laboratory models to develop molecular mechanistic treatments for Dupuytren’s disease.
• David O'Gorman PhD: Primary Dupuytren's Disease cell interactions with the extra-cellular environment: a link to disease progression?
• Christina Raykha MSc:  Insulin-like Growth Factor Binding Protein (IGFBP)-6: A mediator of myofibroblast differentiation in Dupuytren’s Disease?
• Sandip Hindocha MD: Annexin’s role in Dupuytren’s disease – identification of a novel biomarker involved in the apoptotic pathway.
• Sandip Hindocha MD:  Dupuytren’s disease shows profound hematopoietic and mesenchymal stem cell abnormalities involving palmar fat and skin in addition to fascia: Novel implications for pathogenesis and therapy.

6:15 - 7:00 Cocktail Reception

7:00 - 9:00 Dinner Reception and Presentation

• Paul Wylock MD: A Working Day of Guillame Dupuytren

---

Sun May 23

7:00 - 8:00 Breakfast

8:00 - 10:00 Session 5: Surgical Treatments

• Lynn Ketchum MD : Dermofasciectomies and full-thickness skin grafts in the treatment of Dupuytren's contracture: a thirty-six year study.
• Robert Choa MD: Palmar Cutaneous Branches of the Proper Digital Nerves Encountered in Dupuytrens Surgery: a Cadaveric Study.
• Andrey Zhigalo MD: The features of surgical tactic in treatment of patients with severe stages Dupuytren contracture.
• Ilse Degreef PhD MD: Surgical outcome of Dupuytren’s disease. No higher self-reported recurrence after segmental fasciectomy.
• Michael Papaloïzos MD:  Minimizing cutaneous necrosis and delayed healing after surgical treatment for Dupuytren’s contracture : the mini-chevrons incision.
• Bernhard Lukas MD: Treatment of severe Dupuytren contracture by homodigital flaps.
• Massimiliano Tripoli MD: The “Jacobsen flap”  for the treatment of stage III-IV Dupuytren's disease at the little finger: our review of 123 cases.
• Paul Smith MD: A Logical Approach to the PIP Joint in Dupuytren's.
  

10:00 - 10:15 Break

10:15 – 12:15 Session 6: Needle Release and Manual Therapy

• Holger Erne MD: Percutaneous needle fasciotomy a serious alternative?
• Annet Van Rijssen MD: 5-year results of first-ever randomised clinical trial on treatment in Dupuytren's disease: percutaneous needle fasciotomy versus limited fasciectomy.
• Roger Khouri MD: Extensive Percutaneous Aponeurotomy and Lipografting: A new treatment alternative for Dupuytren's disease.
• Bing Siang Gan PhD MD: Needle aponeurotomy for Dupuytren's contracture, the HULC experience.
• John Agee MD: Growing the PIP straight with the Digit Widget.
• Terri Skirven OTR/L CHT: Hand therapy for Dupuytren's: Concepts, practical tips and problems.
• Albrecht Meinel MD: The role of static night splinting after contracture release for Dupuytren’s disease. A preliminary recommendation based on clinical cases.
• Deborah Larson BScOT, MSc: Splinting after contracture release for Dupuytren’s disease (SCoRD) – a pragmatic, multi-centre, randomized controlled trial.
  

12:15 – 1:00 Lunch

1:00 – 3:00 Session 7: Biologic Intervention: Dupuytren's and Related Conditions

• Marie Badalamente PhD: Injectable collagenase clostridium histolyticum for Dupuytren's contracture: results of the cord 1 study.
• Anne Ouellette MD MBA: Outcomes of Apligraf use in Dupuytren's surgery using the McCash incision improves long term outcome.
• Ilse Degreef PhD MD: Cellular implant improves surgical outcome in Dupuytren’s disease.
• Heinrich Seegenschmiedt MD:  Radiotherapy For Primary Or Recurrent Morbus Ledderhose: 12 Year Long-Term Outcome Of A Prospective Phase 2 Trial.
• Wayne Hellstrom MD: Medical Management of Peyronie’s Disease.
• Terry Spilken DPM: Cryotherapy for Plantar Fibromas.
• Chrishan Samuel PhD:  Relaxin: an emerging therapy for fibroproliferative disorders.
• Davor Jurisic PhD MD: Screening of potential prodrugs on cells derived from Dupuytren's disease patients.
• Ilse Degreef PhD MD: Highly-dosed neo-adjuvant tamoxifen improves surgical outcome in segmental fasciectomy in high risk patients with Dupuytren’s disease.
  

3:00 - 3:15 Break

3:15 - 5:15 Session 8: The Future

• Panel Discussions: Global collaboration for Dupuytren’s and related conditions.
• Charles Eaton MD:  Closing remarks.
  

This broad spectrum of Dupuytren related topics will offer new information and new perspectives for everyone, regardless of their background.  Plan to attend this unique event: be part of the effort to find better treatments for Dupuytren's Disease and related conditions!